Formulation and Evaluation of Colchicine Sustained release tablet by using factorial designs

The study on the effect of polymer concentration in vitro drug release profile revealed that there is a change parameters (t50, t80, and MDT) with concentration. Fraction HPMC K4M, K 100 M, Ethyl Cellulose were required to be 15, 10, 7 mg respectively for designing optimized batch F7. rate Colchicine decreased proportionally an increase ethyl K100 M. Also high amount K4M leads less initial sustain effect. A theoretical was generated using pharmacokinetic Colchicine. value t50 t80 found 242 min 529 respectively. similarity factor f2 applied between optimizing batches profile, which indicate decent all profiles (f2 = 68.28 F7). All except F1shows within range. Batch F7 showed highest 68.28) among this also reflected (≈ 256 min) 554 values. 23 full factorial design systemically optimize profile. (X1), Concentration M (X2), EC (X3) selected as independent variables. time 50% released (t50), 80% (t80), f2, mean dissolution (MDT) dependent results have significant To find out mechanism data fitted Korsmeyer-Peppas equation. Batches F1 F3 show Anomalous diffusion-controlled (combined diffusion case II transport).